SNAP23

Across TCGA pan-cancer cohorts, SNAP23 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SNAP23’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SNAP23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNAP23 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

LIHC, HNSC, and KICH are the cancer types where SNAP23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAP23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.801	<.001	8	view →
HNSC	All	III,IV	+0.600	<.001	8	view →
KICH	Female	All	−0.881	<.001	7	view →
LUAD	All	All	−0.311	<.001	7	view →
LUSC	Female	All	−0.635	<.001	6	view →
KIRC	All	All	+0.240	<.001	6	view →
CHOL	Female	All	+1.686	<.001	5	view →
UCEC	All	All	−0.769	<.001	4	view →
STAD	All	II,III,IV	+0.499	<.001	4	view →
COAD	Female	All	−0.421	.015	3	view →
READ	Female	All	−0.654	.001	2	view →
PRAD	All	All	+0.213	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SNAP23–LIHC

Open the LIHC breakdown →