SNAP23

Across TCGA patient cohorts, SNAP23 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAP23-associated genes across cancer lineages are 14-3-3_beta, FASN, and MEK1. Each is linked with SNAP23 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAP23-to-partner and partner-to-SNAP23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SNAP23-low versus SNAP23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAP23→partner) and Y-score (partner→SNAP23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-2.973	.044	.035	3	1
UCEC	FASN →	+0.467	+2.584	.011	.011	3	1
UCEC	MEK1 →	+0.454	+2.321	.007	.034	3	1
UCEC	Paxillin →	+0.251	+2.584	.038	.011	3	1
UCEC	YAP →	+0.145	+3.700	.038	.001	3	1
UCEC	BRD4 →	+0.291	+2.818	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by SNAP23 expression — UCEC

Explore this box plot interactively →