SNAI2

Across TCGA pan-cancer cohorts, SNAI2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SNAI2 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SNAI2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNAI2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where SNAI2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.256	0.662	.005	30	view →
HNSC	DFS	Median	All	0.989	0.920	.012	8	view →
UCEC	DFS	Median	All	0.672	1.000	.024	4	view →
LSCC	DFS	Quartile	All	0.262	0.807	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SNAI2–PDAC (DFS)

Open the PDAC breakdown →