SMYD3-IT1

Across TCGA pan-cancer cohorts, SMYD3-IT1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SMYD3-IT1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMYD3-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMYD3-IT1 expression acts as an unfavorable survival marker, although some lineages such as LAML and LUAD show a favorable association.

HNSC, DLBC, and KIRC are the cancer types where SMYD3-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.429	0.649	.006	70	view →
DLBC	DFS	Tertile	III,IV	0.139	0.780	.008	48	view →
KIRC	DFS	Tertile	All	0.548	0.661	.005	40	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
ACC	OS	Tertile	II,III,IV	0.223	0.706	.033	30	view →
COAD	DFS	Tertile	II,III,IV	0.477	0.693	.004	27	view →
KICH	OS	Quartile	II,III,IV	0.680	0.932	.011	26	view →
SARC	DFS	Tertile	All	0.354	0.531	.014	21	view →
LAML	DFS	Tertile	All	0.595	0.263	.007	18	view →
SKCM	DFS	Quartile	IV	0.040	0.676	.017	14	view →
LUAD	DFS	Quartile	IV	1.000	0.609	.022	14	view →
ESCA	DFS	Median	III,IV	0.402	0.236	.025	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SMYD3-IT1–HNSC (OS)

Open the HNSC breakdown →