SMYD3-IT1

Across TCGA pan-cancer cohorts, SMYD3-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SMYD3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SMYD3-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMYD3-IT1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

KIRP, STAD, and BRCA are the cancer types where SMYD3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMYD3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	+0.230	.005	6	view →
STAD	Male	All	+0.281	.006	4	view →
BRCA	All	All	+0.217	.011	4	view →
COAD	Female	II,III,IV	+0.194	.009	4	view →
LUAD	Female	II,III,IV	−0.205	.027	1	view →
CHOL	All	All	+0.205	.009	1	view →
THCA	All	All	−0.097	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SMYD3-IT1–KIRP

Open the KIRP breakdown →