SMUG1

Across TCGA pan-cancer cohorts, SMUG1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SMUG1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SMUG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SMUG1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where SMUG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.812	0.283	.004	18	view →
UCEC	OS	Quartile	II,III,IV	0.541	1.000	.036	6	view →
CCRCC	DFS	Median	II,III,IV	0.819	0.591	.026	5	view →
LUAD	OS	Quartile	All	1.000	0.679	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SMUG1–PDAC (DFS)

Open the PDAC breakdown →