SMUG1

Across TCGA patient cohorts, SMUG1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMUG1-associated genes across cancer lineages are FASN, ACC_pS79, and VHL. Each is linked with SMUG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMUG1-to-partner and partner-to-SMUG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SMUG1-low versus SMUG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMUG1→partner) and Y-score (partner→SMUG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.565	+3.000	.013	.037	3	1
UCEC	ACC_pS79 →	+0.600	+2.817	.002	.036	3	1
UCEC	VHL →	-0.775	-3.000	.048	.037	3	1
UCEC	c-Kit →	-0.307	-2.980	.022	.036	3	1
UCEC	p70-S6K_pT389 →	-0.236	-3.000	.031	.037	1	2
UCEC	p70-S6K →	+0.219	+3.026	.049	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FASN by SMUG1 expression — UCEC

Explore this box plot interactively →