SMUG1

Across TCGA cell cohorts, SMUG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,111 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SMUG1-associated GO terms across cancer lineages are Spliceosomal tri-snRNP complex assembly, Cell redox homeostasis, and Viral budding via host ESCRT complex. Each is linked with SMUG1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SMUG1-to-partner and partner-to-SMUG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal tri-snRNP complex assembly grouped by SMUG1-low versus SMUG1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMUG1→partner) and Y-score (partner→SMUG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Spliceosomal tri-snRNP complex assembly →	+0.106	+0.533	<.001	<.001	3	8
BLOOD_Lymphoma	Cell redox homeostasis →	+0.066	+0.452	<.001	.007	2	8
STOMACH	Viral budding via host ESCRT complex →	+0.116	+0.419	.001	.003	3	7
BREAST	Heart valve morphogenesis →	-0.084	-0.763	<.001	<.001	3	7
BREAST	Organelle fusion →	+0.052	+0.749	.002	<.001	3	7
OVARY	Spliceosomal snRNP assembly →	+0.080	+0.589	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,111 associations by consensus.

Spliceosomal tri-snRNP complex assembly by SMUG1 expression — OVARY

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