SMU1

Across TCGA patient cohorts, SMU1 mutation is significantly associated with the RNA expression of many other genes, with 1,243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMU1-associated genes across cancer lineages are MIR3928, SENP3-EIF4A1, and FANCG. Each is linked with SMU1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMU1-to-partner and partner-to-SMU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3928 grouped by SMU1-low versus SMU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMU1→partner) and Y-score (partner→SMU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3928 →	+0.318	+2.316	<.001	.005	3	3
UCEC	SENP3-EIF4A1 →	+0.127	+3.269	<.001	.008	3	2
UCEC	FANCG →	+0.565	+3.592	.001	.001	3	2
SKCM	RN7SKP286 →	+0.045	+4.810	<.001	.002	3	2
UCEC	C1QBP →	+0.507	+1.923	.007	.009	3	2
UCEC	DPH1 →	+0.534	+2.415	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,243 associations by consensus.

MIR3928 by SMU1 expression — UCEC

Explore this box plot interactively →