Across TCGA patient cohorts, SMTNL1 mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMTNL1-associated genes across cancer lineages are MRPL50P4, LINC02641, and SAAL1. Each is linked with SMTNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMTNL1-to-partner and partner-to-SMTNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTNL1→partner) and Y-score (partner→SMTNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MRPL50P4 →	+0.111	+5.303	<.001	.006	3	2
UCEC	LINC02641 →	+0.245	+2.605	<.001	.002	3	2
SKCM	SAAL1 →	+0.468	+3.469	.007	.002	3	2
SKCM	EIF1AD →	+0.335	+3.526	.008	.002	3	2
SKCM	PPP2R2D →	+0.396	+3.459	.001	.005	3	2
SKCM	SNORD66 →	+0.200	+2.230	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

Exploration

SMTNL1 survival (RNA) · tumor vs normal (RNA) · all SMTNL1 data types