Across TCGA pan-cancer cohorts, SMTNL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SMTNL1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SMTNL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMTNL1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.
KIRC, KICH, and HNSC are the cancer types where SMTNL1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMTNL1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.