Across TCGA patient cohorts, SMTNL1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMTNL1-associated genes across cancer lineages are eIF4E, Notch1, and PTEN. Each is linked with SMTNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMTNL1-to-partner and partner-to-SMTNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTNL1→partner) and Y-score (partner→SMTNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.221	+3.321	.045	.010	3	1
UCEC	Notch1 →	+0.190	+3.321	.010	.010	3	1
UCEC	PTEN →	-0.450	-3.321	.030	.010	3	1
UCEC	STAT3_pY705 →	-0.532	-3.321	<.001	.010	3	1
UCEC	53BP1 →	+0.420	+3.000	.019	.036	3	1
UCEC	Heregulin →	-0.144	-3.000	.026	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SMTNL1 survival (RNA) · tumor vs normal (RNA) · all SMTNL1 data types