Across TCGA cell cohorts, SMTNL1 mutation is significantly associated with the mutation status of many other genes, with 4,279 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMTNL1-associated genes across cancer lineages are ATP11A, SREBF1, and SUSD2. Each is linked with SMTNL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMTNL1-to-partner and partner-to-SMTNL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTNL1→partner) and Y-score (partner→SMTNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP11A →	+4.297	+4.857	.009	.009	1	3
BREAST	SREBF1 →	+5.297	+5.297	.004	.004	1	3
OVARY	SUSD2 →	+3.240	+4.467	.004	.004	1	3
OVARY	HEPH →	+4.977	+4.415	.007	.007	1	3
LARGE_INTESTINE	VPS16 →	+3.544	+3.321	<.001	<.001	1	3
BLOOD_Leukemia	FLCN →	+4.560	+4.309	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,279 associations by consensus.

Exploration

SMTNL1 survival (RNA) · tumor vs normal (RNA) · all SMTNL1 data types