SMR3B

Across TCGA cell cohorts, SMR3B mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SMR3B-associated genes across cancer lineages are OR1L3, OR56A1, and GALP. Each is linked with SMR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SMR3B-to-partner and partner-to-SMR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by SMR3B-low versus SMR3B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMR3B→partner) and Y-score (partner→SMR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	OR56A1 →	+0.019	+4.977	<.001	.007	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
SKIN	PRAMEF33 →	+0.016	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR1L3 by SMR3B expression — SKIN

Explore this box plot interactively →