SMR3A

Across TCGA patient cohorts, SMR3A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SMR3A-associated genes across cancer lineages are ACVRL1, p53, and p90 RSK. Each is linked with SMR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMR3A-to-partner and partner-to-SMR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by SMR3A-low versus SMR3A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMR3A→partner) and Y-score (partner→SMR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ACVRL1 →	+0.150	+3.182	.030	.009	3	1
SKCM	p53 →	+0.238	+2.182	.010	.033	3	1
SKCM	p90 RSK →	+0.349	+3.000	<.001	.034	3	1
SKCM	XBP1 →	-0.254	-2.321	.037	.035	3	1
SKCM	YB-1_pS102 →	-0.176	-2.321	.039	.035	3	1
SKCM	CD20 →	-0.170	-2.321	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ACVRL1 by SMR3A expression — SKCM

Explore this box plot interactively →