SMR3A

Across TCGA cell cohorts, SMR3A RNA expression is significantly associated with the mutation status of many other genes, with 63 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SMR3A-associated genes across cancer lineages are EPHA8, SIDT1, and EPB41L2. Each is linked with SMR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMR3A-to-partner and partner-to-SMR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPHA8 grouped by SMR3A-low versus SMR3A-high in LUNG_SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMR3A→partner) and Y-score (partner→SMR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EPHA8 →	+4.058	+0.116	.007	<.001	3	1
LUNG_SCLC	SIDT1 →	+4.643	+0.145	.004	<.001	3	1
LUNG_SCLC	EPB41L2 →	+4.643	+0.145	.004	<.001	3	1
LUNG_SCLC	EDEM2 →	+5.643	+0.193	.002	<.001	3	1
LUNG_SCLC	PLEKHG2 →	+5.643	+0.193	.002	<.001	3	1
LUNG_SCLC	REV3L →	+5.643	+0.193	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

EPHA8 by SMR3A expression — LUNG_SCLC

Explore this box plot interactively →