SMPX

Across TCGA cell cohorts, SMPX mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMPX-associated genes across cancer lineages are OR14I1 and SLC22A6. Each is linked with SMPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPX-to-partner and partner-to-SMPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14I1 grouped by SMPX-low versus SMPX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPX→partner) and Y-score (partner→SMPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14I1 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	SLC22A6 →	+0.013	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR14I1 by SMPX expression — LARGE_INTESTINE

Explore this box plot interactively →