SMPDL3B

Across TCGA patient cohorts, SMPDL3B RNA expression is significantly associated with the protein abundance of many other proteins, with 12,694 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMPDL3B-associated proteins across cancer lineages are HID1, RXRA, and SLFN11. Each is linked with SMPDL3B in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPDL3B versus HID1 in HNSC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HID1 →	+0.646	+0.862	<.001	<.001	3	4
LSCC	RXRA →	-0.334	-0.915	<.001	<.001	3	3
LSCC	SLFN11 →	+0.385	+0.761	<.001	<.001	3	3
HNSC	HSPB1 →	-0.758	-0.945	<.001	<.001	3	3
BRCA	HSPB1_S199 →	-0.938	-0.732	<.001	.005	3	3
HNSC	IQGAP2 →	+0.420	+0.715	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,694 associations by consensus.

SMPDL3B vs HID1 — HNSC

Explore this scatter interactively →