SMPDL3B

Across TCGA pan-cancer cohorts, SMPDL3B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SMPDL3B data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMPDL3B RNA is associated with better overall survival. In most high-consensus cancer types, elevated SMPDL3B expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where SMPDL3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.739	0.568	<.001	111	view →
UVM	DFS	Quartile	II,III,IV	0.474	0.884	<.001	77	view →
SKCM	DFS	Tertile	All	0.301	0.181	<.001	61	view →
READ	OS	Median	II,III,IV	1.000	0.478	.005	58	view →
LUSC	OS	Median	All	0.722	0.822	.006	51	view →
KIRC	DFS	Quartile	IV	0.586	0.272	.005	49	view →
BLCA	OS	Quartile	III,IV	0.738	0.527	.012	41	view →
OV	DFS	Median	II,III,IV	0.344	0.414	.014	32	view →
KIRP	DFS	Tertile	II,III,IV	0.312	1.000	.008	30	view →
THCA	OS	Tertile	II,III,IV	0.987	0.901	.020	29	view →
SCLC	DFS	Quartile	All	0.860	0.224	<.001	24	view →
UCS	DFS	Median	II,III,IV	0.283	0.576	.010	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SMPDL3B–HNSC (OS)

Open the HNSC breakdown →