SMPDL3B

Across TCGA patient cohorts, SMPDL3B protein abundance is significantly associated with the RNA expression of many other genes, with 8,848 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMPDL3B-associated genes across cancer lineages are KCTD14, ACOXL, and TMEM246-AS1. Each is linked with SMPDL3B in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPDL3B versus KCTD14 in HNSC, with a Pearson correlation of 0.23.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KCTD14 →	+0.867	+0.478	<.001	.004	3	4
OV	ACOXL →	+0.633	+1.172	.003	.003	3	4
LSCC	TMEM246-AS1 →	-0.594	-0.393	<.001	<.001	3	3
UCEC	NR3C1 →	-0.598	-0.432	<.001	<.001	3	3
OV	CHDH →	+0.958	+1.328	<.001	<.001	3	3
LSCC	RASSF6 →	+0.901	+0.397	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,848 associations by consensus.

SMPDL3B vs KCTD14 — HNSC

Explore this scatter interactively →