SMPDL3B

Across TCGA patient cohorts, SMPDL3B mutation is significantly associated with the RNA expression of many other genes, with 1,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPDL3B-associated genes across cancer lineages are RNA5SP423, RNA5SP413, and ATAD3A. Each is linked with SMPDL3B in more than 2 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP423 grouped by SMPDL3B-low versus SMPDL3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP423 →	+0.750	+1.939	<.001	.007	3	3
UCEC	RNA5SP413 →	+1.225	+2.125	<.001	.001	3	2
UCEC	ATAD3A →	+0.502	+3.609	.001	.001	3	2
UCEC	PRC1 →	+0.627	+2.415	.009	.003	3	2
UCEC	RNA5SP417 →	+0.597	+2.236	<.001	.004	3	2
UCEC	RNA5SP422 →	+1.097	+2.211	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,104 associations by consensus.

RNA5SP423 by SMPDL3B expression — UCEC

Explore this box plot interactively →