SMPDL3B

Across TCGA patient cohorts, SMPDL3B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPDL3B-associated genes across cancer lineages are VHL, YAP, and 4E-BP1. Each is linked with SMPDL3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SMPDL3B-low versus SMPDL3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.981	-3.169	.001	.018	3	2
UCEC	YAP →	+0.146	+2.469	.031	.010	3	2
UCEC	4E-BP1 →	+0.319	+2.999	.008	.035	3	2
UCEC	14-3-3_beta →	-0.143	-1.986	.001	.032	2	2
UCEC	A-Raf_pS299 →	-0.127	-2.999	.018	.035	3	1
UCEC	Ku80 →	+0.386	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

VHL by SMPDL3B expression — UCEC

Explore this box plot interactively →