SMPDL3B

Across TCGA cell cohorts, SMPDL3B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,288 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMPDL3B-associated GO terms across cancer lineages are Regulation of mitochondrion organization, Keratinocyte development, and Establishment of epithelial cell apical/basal polarity. Each is linked with SMPDL3B in more than 8 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrion organization grouped by SMPDL3B-low versus SMPDL3B-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of mitochondrion organization →	+0.062	+0.786	<.001	<.001	3	9
SKIN	Keratinocyte development →	-0.502	-0.765	.001	.002	3	9
BREAST	Establishment of epithelial cell apical/basal polarity →	-0.181	-2.295	<.001	<.001	3	9
LIVER	Hepatocyte apoptotic process →	+0.193	+1.717	.001	.003	3	9
STOMACH	Negative regulation of inflammatory response to wounding →	+0.186	+2.573	<.001	<.001	3	9
OVARY	Regulation of inner ear receptor cell differentiation →	+0.682	+1.573	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,288 associations by consensus.

Regulation of mitochondrion organization by SMPDL3B expression — SKIN

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