SMPDL3B

Across TCGA cell cohorts, SMPDL3B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMPDL3B-associated genes across cancer lineages are MBD3L5, GJD2, and TBC1D21. Each is linked with SMPDL3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPDL3B-to-partner and partner-to-SMPDL3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by SMPDL3B-low versus SMPDL3B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3B→partner) and Y-score (partner→SMPDL3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GJD2 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10Q1 →	+0.120	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.347	<.001	.001	3	1
LARGE_INTESTINE	PFN3 →	+0.151	+4.882	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MBD3L5 by SMPDL3B expression — SKIN

Explore this box plot interactively →