SMPDL3A

Across TCGA patient cohorts, SMPDL3A protein abundance is significantly associated with the RNA expression of many other genes, with 10,927 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMPDL3A-associated genes across cancer lineages are ORC6, FGD1, and SLC1A1. Each is linked with SMPDL3A in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPDL3A-to-partner and partner-to-SMPDL3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPDL3A versus ORC6 in BRCA, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3A→partner) and Y-score (partner→SMPDL3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ORC6 →	-0.737	-0.426	.005	.007	3	4
LSCC	FGD1 →	-0.549	-0.451	.003	<.001	3	3
BRCA	SLC1A1 →	+1.427	+0.461	.001	.001	3	3
BRCA	CGNL1 →	+0.920	+0.521	.001	<.001	3	3
BRCA	FMO5 →	+1.401	+0.646	<.001	<.001	3	3
UCEC	TBC1D8B →	+0.714	+0.513	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,927 associations by consensus.

SMPDL3A vs ORC6 — BRCA

Explore this scatter interactively →