Across TCGA patient cohorts, SMOC1 mutation is significantly associated with the RNA expression of many other genes, with 1,167 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMOC1-associated genes across cancer lineages are SLC22A17, RNU4-65P, and CORO2B. Each is linked with SMOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMOC1-to-partner and partner-to-SMOC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC1→partner) and Y-score (partner→SMOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC22A17 →	-1.191	-3.087	<.001	<.001	3	3
UCEC	RNU4-65P →	+0.160	+3.038	<.001	.006	3	3
SKCM	CORO2B →	-1.620	-2.396	<.001	.003	3	3
LUSC	RNU6-23P →	+0.224	+4.706	<.001	.007	3	3
HNSC	RNU6-1249P →	+0.370	+6.132	<.001	.001	3	2
UCEC	MIR98 →	+0.279	+2.316	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,167 associations by consensus.

Exploration

SMOC1 survival (RNA) · tumor vs normal (RNA) · all SMOC1 data types