Across TCGA cell cohorts, SMOC1 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMOC1-associated genes across cancer lineages are CCNC, STXBP3, and RPAP2. Each is linked with SMOC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMOC1-to-partner and partner-to-SMOC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMOC1→partner) and Y-score (partner→SMOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCNC →	+0.712	+3.212	<.001	.006	3	1
LARGE_INTESTINE	STXBP3 →	+0.540	+3.212	.001	.006	3	1
LARGE_INTESTINE	RPAP2 →	+0.749	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ITGA10 →	+0.343	+3.212	.006	.006	3	1
LARGE_INTESTINE	CHAC2 →	+0.700	+3.212	.009	.006	3	1
LARGE_INTESTINE	HSPD1 →	+0.533	+3.125	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

Exploration

SMOC1 survival (RNA) · tumor vs normal (RNA) · all SMOC1 data types