SMIM8

Across TCGA cell cohorts, SMIM8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,451 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SMIM8-associated GO terms across cancer lineages are Regulation of mitochondrial transcription, Subtelomeric heterochromatin formation, and Regulation of body fluid levels. Each is linked with SMIM8 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMIM8-to-partner and partner-to-SMIM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial transcription grouped by SMIM8-low versus SMIM8-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM8→partner) and Y-score (partner→SMIM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of mitochondrial transcription →	+0.137	+0.821	<.001	<.001	3	13
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.082	+0.467	.002	.003	3	13
OVARY	Regulation of body fluid levels →	-0.086	-0.608	<.001	.005	3	13
OVARY	7-methylguanosine RNA capping →	+0.125	+0.578	<.001	<.001	3	12
STOMACH	Negative regulation of double-strand break repair via homologous recombination →	+0.094	+0.906	.003	.007	3	12
BONE	Cell-substrate adhesion →	-0.150	-0.563	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,451 associations by consensus.

Regulation of mitochondrial transcription by SMIM8 expression — KIDNEY

Explore this box plot interactively →