SMIM43

Across TCGA patient cohorts, SMIM43 mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM43-associated genes across cancer lineages are USP9YP4, DNM1P28, and MIR3908. Each is linked with SMIM43 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM43-to-partner and partner-to-SMIM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP4 grouped by SMIM43-low versus SMIM43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM43→partner) and Y-score (partner→SMIM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	USP9YP4 →	+0.067	+5.362	<.001	.005	3	2
SKCM	DNM1P28 →	+0.104	+5.224	<.001	.007	3	2
BRCA	MIR3908 →	+0.351	+6.112	<.001	.002	3	1
SKCM	OR52X1P →	+0.091	+5.097	<.001	.008	3	1
SKCM	OR7E53P →	+0.091	+5.292	<.001	.006	3	1
SKCM	AK4P2 →	+0.078	+5.037	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

USP9YP4 by SMIM43 expression — SKCM

Explore this box plot interactively →