SMIM4

Across TCGA patient cohorts, SMIM4 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMIM4-associated genes across cancer lineages are RN7SL248P, MIR4510, and RN7SKP229. Each is linked with SMIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMIM4-to-partner and partner-to-SMIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SMIM4-low versus SMIM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM4→partner) and Y-score (partner→SMIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.212	+5.722	<.001	.001	3	2
UCEC	MIR4510 →	+0.489	+5.453	<.001	.002	3	2
UCEC	RN7SKP229 →	+0.219	+4.621	.001	.008	3	2
UCEC	C11orf40 →	+0.403	+4.374	<.001	.007	3	1
UCEC	OR5J2 →	+0.144	+4.871	.007	.002	3	1
UCEC	MIR98 →	+0.954	+5.386	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

RN7SL248P by SMIM4 expression — UCEC

Explore this box plot interactively →