SMIM35

Across TCGA patient cohorts, SMIM35 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,323 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMIM35-associated proteins across cancer lineages are TMPRSS4, ALDH1A1, and PIR. Each is linked with SMIM35 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMIM35-to-partner and partner-to-SMIM35 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMIM35 versus TMPRSS4 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM35→partner) and Y-score (partner→SMIM35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMPRSS4 →	+1.097	+0.633	<.001	<.001	3	4
HNSC	ALDH1A1 →	+0.761	+0.633	<.001	<.001	3	4
LSCC	PIR →	+0.680	+0.445	<.001	<.001	3	3
LSCC	TKT →	+0.394	+0.545	<.001	<.001	3	3
LSCC	RAPGEFL1_S313 →	+1.863	+0.744	<.001	<.001	3	3
BRCA	SPN_S355 →	+0.845	+0.224	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,323 associations by consensus.

SMIM35 vs TMPRSS4 — LSCC

Explore this scatter interactively →