SMIM34A

Across TCGA patient cohorts, SMIM34A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,544 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible SMIM34A-associated GO terms across cancer lineages are Positive regulation of blood-brain barrier permeability, Mitochondrial translational elongation, and Neuron projection arborization. Each is linked with SMIM34A in more than 2 cancer types. Because this analysis shows association rather than direction, both SMIM34A-to-partner and partner-to-SMIM34A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of blood-brain barrier permeability grouped by SMIM34A-low versus SMIM34A-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMIM34A→partner) and Y-score (partner→SMIM34A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Positive regulation of blood-brain barrier permeability →	+0.156	+0.005	<.001	.001	3	3
KIRC	Mitochondrial translational elongation →	+0.104	+0.011	<.001	<.001	3	3
LUAD	Neuron projection arborization →	+0.039	+0.004	.007	<.001	3	3
KIRC	Regulation of lipid catabolic process →	+0.074	+0.006	<.001	<.001	3	3
KIRC	Protein histidyl modification to diphthamide →	+0.070	+0.011	<.001	<.001	3	3
KIRC	Maintenance of organelle location →	+0.108	+0.011	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,544 associations by consensus.

Positive regulation of blood-brain barrier permeability by SMIM34A expression — KIRC

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