SMIM28

Across TCGA pan-cancer cohorts, SMIM28 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SMIM28 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SMIM28 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMIM28 expression acts as an unfavorable survival marker, although some lineages such as READ and LIHC show a favorable association.

KIRC, BRCA, and LUAD are the cancer types where SMIM28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.497	0.679	<.001	87	view →
BRCA	OS	Tertile	IV	0.291	0.848	<.001	36	view →
LUAD	OS	Tertile	III,IV	0.374	0.700	.013	36	view →
ACC	DFS	Tertile	All	0.383	0.797	.007	33	view →
UVM	DFS	Tertile	All	0.141	0.744	.024	18	view →
READ	DFS	Tertile	IV	0.944	0.382	.001	18	view →
THCA	OS	Tertile	II,III,IV	0.825	0.967	.005	12	view →
MESO	OS	Tertile	IV	0.168	0.627	.010	9	view →
LIHC	OS	Tertile	II,III,IV	1.000	0.717	.023	9	view →
PRAD	OS	Quartile	All	1.000	0.979	.036	4	view →
STAD	OS	Tertile	IV	0.708	0.348	.030	3	view →
KIRP	DFS	Tertile	All	0.778	0.880	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

SMIM28–KIRC (OS)

Open the KIRC breakdown →