SMIM28

Across TCGA pan-cancer cohorts, SMIM28 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SMIM28’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMIM28 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM28 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and READ are the cancer types where SMIM28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.001	<.001	8	view →
KIRC	Male	All	−0.051	<.001	6	view →
READ	All	All	−1.450	<.001	5	view →
KICH	All	All	−0.091	.001	5	view →
THCA	All	All	−0.041	.001	3	view →
PRAD	All	All	+0.713	<.001	2	view →
LIHC	Male	All	−0.042	.006	2	view →
HNSC	Male	IV	+0.032	.027	2	view →
STAD	All	All	−0.232	.029	1	view →
KIRP	Male	All	−0.077	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SMIM28–COAD

Open the COAD breakdown →