SMIM24

Across TCGA pan-cancer cohorts, SMIM24 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SMIM24 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SMIM24 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SMIM24 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, SCLC, and BRCA are the cancer types where SMIM24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.709	0.530	<.001	172	view →
SCLC	OS	Median	II,III,IV	0.668	0.304	<.001	76	view →
BRCA	DFS	Tertile	All	0.616	0.449	<.001	74	view →
MESO	OS	Tertile	IV	0.213	0.858	.001	72	view →
KIRP	OS	Tertile	II,III,IV	0.757	0.222	.016	48	view →
LUSC	DFS	Tertile	II,III,IV	0.832	0.276	.001	27	view →
HNSC	OS	Median	III,IV	0.808	0.684	.010	16	view →
THYM	DFS	Quartile	All	0.948	0.519	.008	15	view →
BLCA	DFS	Quartile	All	0.597	0.438	.014	15	view →
UVM	DFS	Quartile	III,IV	0.906	0.420	.003	14	view →
ESCA	OS	Median	All	0.617	1.000	.009	12	view →
SKCM	OS	Tertile	All	0.427	0.267	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SMIM24–KIRC (DFS)

Open the KIRC breakdown →