SMIM24

Across TCGA pan-cancer cohorts, SMIM24 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SMIM24’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SMIM24 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM24 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, HNSC, and LUAD are the cancer types where SMIM24 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM24 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−3.797	<.001	11	view →
HNSC	All	All	+0.493	<.001	11	view →
LUAD	Male	All	+0.979	<.001	8	view →
KIRC	All	All	−0.961	<.001	8	view →
THCA	All	All	+0.797	<.001	8	view →
BRCA	All	III,IV	−0.545	<.001	6	view →
LUSC	All	All	+0.498	<.001	5	view →
READ	Male	All	−1.933	.030	3	view →
BLCA	All	All	+0.711	.016	3	view →
LIHC	All	All	−1.483	.004	2	view →
UCEC	All	All	+1.083	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SMIM24–KIRP

Open the KIRP breakdown →