SMIM2-IT1

Across TCGA pan-cancer cohorts, SMIM2-IT1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SMIM2-IT1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMIM2-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM2-IT1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

UCEC, KICH, and MESO are the cancer types where SMIM2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.721	0.861	<.001	102	view →
KICH	OS	Tertile	III,IV	0.190	0.763	.001	75	view →
MESO	OS	Tertile	III,IV	0.036	0.563	<.001	63	view →
LUSC	OS	Tertile	III,IV	0.471	0.735	.001	48	view →
BRCA	OS	Tertile	IV	0.375	0.907	.007	33	view →
PAAD	DFS	Median	All	0.511	0.250	.003	20	view →
SKCM	OS	Tertile	II,III,IV	0.915	0.684	.014	12	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
THYM	DFS	Median	II,III,IV	1.000	0.832	.006	7	view →
GBM	OS	Tertile	All	0.223	0.398	.041	6	view →
OV	OS	Quartile	IV	0.827	0.562	.024	6	view →
PCPG	DFS	Tertile	All	0.774	0.947	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

SMIM2-IT1–UCEC (DFS)

Open the UCEC breakdown →