SMIM2-IT1

Across TCGA pan-cancer cohorts, SMIM2-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SMIM2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMIM2-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM2-IT1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and READ are the cancer types where SMIM2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.367	<.001	11	view →
KICH	All	All	−0.168	<.001	5	view →
READ	All	All	−0.258	.006	2	view →
THCA	All	All	+0.160	.002	2	view →
UCEC	All	II,III,IV	−0.110	.040	2	view →
BRCA	All	III,IV	−0.079	.009	2	view →
LIHC	All	All	+0.037	.012	2	view →
STAD	Female	III,IV	−0.255	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SMIM2-IT1–COAD

Open the COAD breakdown →