SMIM15P2

Across TCGA pan-cancer cohorts, SMIM15P2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SMIM15P2 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SMIM15P2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM15P2 expression acts as an unfavorable survival marker, although some lineages such as LAML and STAD show a favorable association.

CESC, LAML, and ESCA are the cancer types where SMIM15P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.301	0.792	<.001	32	view →
LAML	DFS	Quartile	All	0.794	0.461	.005	24	view →
ESCA	OS	Quartile	IV	0.127	0.601	.017	18	view →
STAD	OS	Tertile	IV	0.708	0.256	.014	12	view →
LUAD	OS	Median	II,III,IV	0.314	0.136	.021	10	view →
HNSC	OS	Quartile	II,III,IV	0.625	0.823	.023	7	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	6	view →
COAD	DFS	Median	III,IV	0.569	0.204	.006	6	view →
BLCA	DFS	Quartile	All	0.155	0.463	.031	5	view →
KIRC	OS	Tertile	All	0.747	0.577	.020	4	view →
LGG	OS	Tertile	All	0.351	0.653	.008	4	view →
MESO	OS	Quartile	III,IV	0.502	0.266	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SMIM15P2–CESC (DFS)

Open the CESC breakdown →