SMIM15P2

Across TCGA pan-cancer cohorts, SMIM15P2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SMIM15P2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMIM15P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMIM15P2 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where SMIM15P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMIM15P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.685	<.001	10	view →
LIHC	Male	All	+0.637	<.001	7	view →
THCA	All	III,IV	−0.653	.003	6	view →
COAD	All	All	−0.280	.014	3	view →
KIRC	All	All	+0.280	.004	3	view →
READ	All	III,IV	+1.325	.004	2	view →
STAD	Female	All	−0.671	.033	2	view →
PRAD	All	All	−0.213	.036	2	view →
ESCA	All	All	−0.593	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SMIM15P2–HNSC

Open the HNSC breakdown →