Across TCGA pan-cancer cohorts, SMIM15P1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SMIM15P1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where SMIM15P1 RNA is repressed in tumor relative to normal tissue. In most cancer types SMIM15P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where SMIM15P1 tumor–normal differential expression is most reproducible.