SMIM15-AS1

Across TCGA pan-cancer cohorts, SMIM15-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SMIM15-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SMIM15-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM15-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and CESC show a favorable association.

UVM, READ, and CESC are the cancer types where SMIM15-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.229	0.721	.005	57	view →
READ	OS	Quartile	All	0.914	0.452	.009	44	view →
CESC	OS	Tertile	II,III,IV	0.890	0.729	.013	32	view →
BLCA	DFS	Median	All	0.201	0.488	.005	28	view →
THCA	DFS	Tertile	II,III,IV	0.527	0.810	.009	28	view →
HNSC	OS	Tertile	IV	0.795	0.635	.011	28	view →
UCS	DFS	Quartile	III,IV	0.565	0.104	.015	24	view →
LGG	OS	Tertile	All	0.851	0.965	.002	23	view →
UCEC	DFS	Quartile	II,III,IV	0.642	0.833	.012	22	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
ESCA	OS	Tertile	IV	0.372	0.743	.024	15	view →
BRCA	OS	Quartile	IV	0.858	0.212	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SMIM15-AS1–UVM (DFS)

Open the UVM breakdown →