SMIM12P1

Across TCGA pan-cancer cohorts, SMIM12P1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated SMIM12P1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SMIM12P1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMIM12P1 expression acts as an unfavorable survival marker, although some lineages such as BRCA show a favorable association.

READ, SKCM, and PAAD are the cancer types where SMIM12P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	III,IV	0.027	0.761	<.001	45	view →
SKCM	OS	Tertile	III,IV	0.281	0.709	<.001	39	view →
PAAD	OS	Tertile	II,III,IV	0.112	0.586	<.001	36	view →
TGCT	DFS	Tertile	II,III,IV	0.015	0.919	<.001	36	view →
LIHC	DFS	Quartile	All	0.361	0.606	.004	33	view →
KIRC	DFS	Tertile	All	0.497	0.650	.008	30	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
LUSC	OS	Tertile	All	0.412	0.665	.015	12	view →
THCA	OS	Tertile	IV	0.520	0.857	.015	12	view →
CHOL	DFS	Tertile	III,IV	0.118	0.476	.031	9	view →
BRCA	OS	Tertile	All	1.000	0.960	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SMIM12P1–READ (DFS)

Open the READ breakdown →