SMG9

Across TCGA patient cohorts, SMG9 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG9-associated genes across cancer lineages are ATM, eIF4E, and ERK2. Each is linked with SMG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG9-to-partner and partner-to-SMG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SMG9-low versus SMG9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG9→partner) and Y-score (partner→SMG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.658	-2.986	.002	.035	3	2
UCEC	eIF4E →	+0.237	+3.169	.020	.019	3	1
UCEC	ERK2 →	+0.296	+3.584	.001	.002	3	1
UCEC	JNK2 →	+0.237	+2.817	.013	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.213	+2.472	.033	.011	3	1
UCEC	PCNA →	+0.291	+2.459	.005	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATM by SMG9 expression — UCEC

Explore this box plot interactively →