SMG9

Across TCGA pan-cancer cohorts, SMG9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SMG9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SMG9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMG9 is over-expressed in tumor.

KIRC, BLCA, and COAD are the cancer types where SMG9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMG9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.443	<.001	12	view →
BLCA	Female	III,IV	+1.080	<.001	11	view →
COAD	Male	IV	+1.029	<.001	11	view →
HNSC	All	IV	+0.706	<.001	11	view →
LIHC	Female	II,III,IV	+1.651	<.001	9	view →
STAD	Male	II,III,IV	+1.149	<.001	8	view →
BRCA	All	III,IV	+0.600	<.001	8	view →
THCA	Male	All	+0.410	<.001	7	view →
UCEC	All	III,IV	+0.667	<.001	6	view →
CHOL	Male	All	+2.583	<.001	5	view →
LUAD	All	II,III,IV	+0.280	.005	5	view →
ESCA	All	All	+0.995	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SMG9–KIRC

Open the KIRC breakdown →