SMG9

Across TCGA cell cohorts, SMG9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,962 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SMG9-associated GO terms across cancer lineages are Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Negative regulation of calcium ion export across plasma membrane, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with SMG9 in more than 14 cancer types. Because this analysis shows association rather than direction, both SMG9-to-partner and partner-to-SMG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by SMG9-low versus SMG9-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG9→partner) and Y-score (partner→SMG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.107	+0.796	<.001	.007	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.078	+0.925	<.001	<.001	3	13
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.140	+0.765	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of telomere capping →	+0.118	+1.038	<.001	<.001	3	13
BONE	Regulation of protein localization to centrosome →	+0.127	+0.851	<.001	<.001	3	13
BONE	Centriole replication →	+0.126	+0.781	.005	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,962 associations by consensus.

Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by SMG9 expression — LUNG_SCLC

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