SMG9

Across TCGA cell cohorts, SMG9 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMG9-associated genes across cancer lineages are R3HDML, BANF2, and REG3G. Each is linked with SMG9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMG9-to-partner and partner-to-SMG9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by SMG9-low versus SMG9-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG9→partner) and Y-score (partner→SMG9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
SKIN	TMEM210 →	+0.048	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	PTH →	+0.034	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM71B →	+0.006	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

R3HDML by SMG9 expression — BLOOD_Lymphoma

Explore this box plot interactively →