SMG8

Across TCGA patient cohorts, SMG8 mutation is significantly associated with the RNA expression of many other genes, with 2,941 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMG8-associated genes across cancer lineages are MON1A, SIRT6, and NUDT4P2. Each is linked with SMG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMG8-to-partner and partner-to-SMG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MON1A grouped by SMG8-low versus SMG8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMG8→partner) and Y-score (partner→SMG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MON1A →	+0.341	+2.180	<.001	.001	3	3
LUSC	SIRT6 →	+0.442	+3.459	.002	.005	3	3
UCEC	NUDT4P2 →	+0.031	+2.314	<.001	.001	3	3
LUSC	RNU6-301P →	+0.660	+3.683	.002	.002	3	3
CESC	MIR7845 →	+0.560	+4.266	<.001	.001	3	3
BLCA	RNU6-766P →	+0.343	+3.910	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,941 associations by consensus.

MON1A by SMG8 expression — UCEC

Explore this box plot interactively →