SMG7-AS1

Across TCGA pan-cancer cohorts, SMG7-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SMG7-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SMG7-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMG7-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and HNSC show a favorable association.

KICH, BLCA, and THCA are the cancer types where SMG7-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.387	0.944	.001	60	view →
BLCA	DFS	Median	II,III,IV	0.251	0.408	.002	56	view →
THCA	OS	Median	IV	0.600	1.000	.004	46	view →
ACC	DFS	Quartile	All	0.325	0.757	<.001	43	view →
READ	OS	Median	II,III,IV	0.815	0.443	<.001	35	view →
HNSC	DFS	Median	IV	0.396	0.267	.002	33	view →
KIRC	OS	Quartile	All	0.767	0.578	.002	31	view →
LGG	OS	Quartile	All	0.714	0.964	<.001	25	view →
KIRP	DFS	Quartile	All	0.793	0.941	.007	17	view →
PCPG	OS	Tertile	All	0.905	1.000	.021	17	view →
LUSC	DFS	Median	III,IV	0.253	0.514	.006	16	view →
UCEC	OS	Quartile	II,III,IV	0.680	0.849	.016	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SMG7-AS1–KICH (DFS)

Open the KICH breakdown →