SMG7-AS1

Across TCGA pan-cancer cohorts, SMG7-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SMG7-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SMG7-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMG7-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where SMG7-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMG7-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.426	<.001	10	view →
THCA	All	II,III,IV	−0.590	<.001	8	view →
HNSC	Male	III,IV	+0.329	<.001	8	view →
LIHC	Male	All	+0.272	<.001	7	view →
BLCA	Female	III,IV	+0.488	<.001	6	view →
KIRP	Female	II,III,IV	+0.776	.006	5	view →
STAD	Male	All	+0.391	.001	5	view →
BRCA	All	All	+0.137	.001	4	view →
KICH	All	All	−0.319	<.001	3	view →
READ	All	III,IV	+0.554	.011	2	view →
CHOL	All	All	+0.524	.008	2	view →
LUSC	All	All	+0.209	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SMG7-AS1–COAD

Open the COAD breakdown →